Figure 1:

Personal Genome Project Canada (PGPC) workflow. Potential participants in the project must meet eligibility criteria and undergo an entrance examination. Consent is sought and reaffirmed at stages throughout the process. Research ethics board protocols and consents, and genome data files are available at www.personalgenomes.ca. For adjunct analyses, we also assayed 55 samples using high-resolution microarrays (Affymetrix Cytoscan-HD) (Appendix 1), and we generated induced pluripotent stem cell lines for 3 individuals (Figure S4, Appendix 1).