REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Bacterial and Virus Strains
Biological Samples
Chemicals, Peptides, and Recombinant Proteins
Critical Commercial Assays
Deposited Data
Experimental Models: Cell Lines
Experimental Models: Organisms/Strains
Oligonucleotides
Recombinant DNA
Software and Algorithms
Python/2.7.3	Python	https://www.python.org/
Numpy/1.13.1	Walt et al. (2011)	http://www.numpy.org/
GraphLab/2.1	Low et al. (2012)	https://turi.com/
Scipy/0.19.1	Jones et al. (2014)	https://www.scipy.org/
scikit-learn/0.17.0	Pedregosa et al. (2011)	http://scikit-learn.org/stable/
R version 3.2.3	R	https://cran.r-project.org/
ggplot2/2.2.1	Wickham (2016)	http://ggplot2.org/
reshape2/1.4.2	Wickham (2016)	https://cran.r-project.org/web/packages/reshape2/index.html
DSSP	Kabsch and Sander(1983)	http://swift.cmbi.ru.nl/gv/dssp/
Polyphen2 (annotations and predictions)	Adzhubei et al. (2010)	http://genetics.bwh.harvard.edu/pph2/dokuwiki/downloads
SIFT predictions	Ng and Henikoff (2002)	http://sift.jcvi.org/
EVmutation predictions	Hopf et al. (2017)	https://marks.hms.harvard.edu/evmutation/
SNAP2 predictions	Hecht M, Bromberg Y & Rost B (2015)	https://rostlab.org/services/snap2web/
Envision	This study	https://github.com/FowlerLab/Envision2017
Other
TEM1 β-lactamase	Firnberg	PubmedID: 24567513
Yap65 (WW domain)	Fowler	20711194
PSD95 (Pdz3 domain)	McLaughlin	23041932
Brca1 (RING domain)- E3 ligase activity	Starita	25823446
Brca1 (RING domain)- Bard1 binding	Starita	25823446
Aminoglycoside kinase	Melnikov	24914046
E4B (U-box domain)	Starita	23509263
Hsp90	Mishra	27068472
Ubiquitin	Roscoe	23376099
Pab1 (RRM domain)	Melamed	25671604
Ubiquitin - E1 activity	Roscoe	24862281
Protein G (IgG domain)	Olson	25455030