Table 2.
Effects of Methylprednisolone Pulse Therapy on Various Parameters Recorded by the Continuous Glucose Monitoring System.
| Baseline | MP pulse first cycle | p value | |
|---|---|---|---|
| Mean sensor glucose level (mg/dL) | 98.8±6.3 | 155.2±11.0 | 0.043 |
| SD (mg/dL) | 19.2±5.2 | 38.5±3.8 | 0.043 |
| MAGE (mg/dL) | 63.2±19.1 | 103.1±20.9 | 0.043 |
| Minimum sensor glucose level (mg/dL) | 64.8±6.8 | 93.6±14.0 | 0.043 |
| Maximum sensor glucose level (mg/dL) | 156.6±21.3 | 255.6±21.3 | 0.042 |
| Pre-meal sensor glucose level | |||
| Breakfast (mg/dL) | 88.8±21.9 | 97.4±13.6 | 0.498 |
| Lunch (mg/dL) | 88.2±10.5 | 134.2±10.0 | 0.043 |
| Dinner (mg/dL) | 95.8±10.5 | 150.0±24.9 | 0.043 |
| Postprandial peak sensor glucose level | |||
| Breakfast (mg/dL) | 135.8±25.7 | 188.0±24.6 | 0.068 |
| Lunch (mg/dL) | 129.8±13.8 | 230.8±5.5 | 0.043 |
| Dinner (mg/dL) | 151.6±19.0 | 255.6±21.3 | 0.043 |
| AUC ≥180 (mg/dL/day) | 0±0 | 7.8±4.1 | 0.043 |
| AOC <70 (mg/dL/day) | 0±0 | 0±0 | 1.000 |
Data are mean±standard deviation.
p value for baseline vs MP first cycle on day-3, by Wilcoxon signed rank test.
MP: methylprednisolone, SD: standard deviation, MAGE: mean amplitude of glycemic excursions, AUC ≥180: area under the curve for sensor glucose levels ≥180 mg/dL, AOC <70: area over the curve for sensor glucose levels <70 mg/dL