Fig. 7.

Group quantification of spiking (A) and LFP (B) responses in area 3b as a function of stimulus frequency, and summary of percentage of spike-LFP dissociation in control and input-deprived deafferented cases (C). A The mean response efficacy (RE, solid lines) to different stimulus frequencies declined progressively in deafferented area 3b (red), and was significantly lower than in normal cases (blue) (*P < 0.05, except for 2-Hz stimulus). The firing rates in normal cortex were also significantly higher than in deafferented cortex. B The mean power of evoked LFPs in area 3b also decreased with increasing stimulus frequency. The LFP signal was persistently and robustly modulated by tactile stimulation under all conditions, and there was no difference between signals in normal versus deafferented cortex (*P > 0.05). C Summary of spike-LFP dissociation as a function of stimulus frequency in area 3b of normal and input-deprived subjects. With increasing stimulation frequency, the LFP response was more often dissociated from spiking activity in the input-deprived cases (*P < 0.05). Modified from Wang Z, et al., Exp Neurol 2013 [69].