Table 1.
Electrophysiological parameters of sympathetic neurons in ex vivo recordings.
| Normal | SNL | LID | |
|---|---|---|---|
| Max dV/dt (V/s) | 170.4 ± 6.9 | 170.2 ± 7.2 | 185.9 ± 15.1 |
| Threshold (mV) | −32.4 ± 0.9 | −32.2 ± 0.8 | −34.8 ± 1.9 |
| AP width (ms) | 2.39 ± 0.04 | 2.61 ± 0.08* | 2.28 ± 0.09 |
| Peak AP (mV) | 24.7 ± 1.2 | 24.8 ± 1.2 | 22.4 ± 2.0 |
| Rheobase (nA) | 0.53 ± 0.08 | 0.35 ± 0.05* | 0.31 ± 0.09 |
| R m (MΩ) | 30.7 ± 1.5 | 38.8 ± 2.1** | 43.6 ± 4.0** |
| V rest (mV) | −53.1 ± 1.0 | −52.5 ± 1.0 | −55.5 ± 1.9 |
| Max # AP | 10.3 ± 0.8 | 10.2 ± 0.8 | 10.5 ± 1.2 |
| Number of cells | 71 | 83 | 25 |
Normal: data from SG3 and SG4 isolated from normal rats. SNL: data from SG3 and SG4 isolated 7 days after L5 spinal nerve ligation. LID: data from SG4 isolated 3–4 days after local inflammation of the DRG.
AP, action potential; Max dV/dt, maximum rate of voltage change during AP upstroke; peak AP, maximum voltage during AP; R m, membrane input resistance; V rest, resting membrane potential; Max #AP, maximum number of AP evoked by 270 ms suprathreshold stimulus.
* P < 0.05; ** P < 0.01; significantly different from normal value, Mann–Whitney test.