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. 2018 Feb 5;8:2431. doi: 10.1038/s41598-018-20859-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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HOXD3 induces VEGFR promoter activity in HCCs. (A) The expression of VEGFR in tumor tissues were analyzed by TCGA data base. (B) The expression levels of VEGFR mRNA in HCC and healthy tissues were analyzed by qRT-PCR. (C) The relationship between HOXD3 and VEGFR were assayed by Pearson’s r. (D) Schematic diagram of the putative VEGFR promoter with one potential HOXD3 response element. (E) The interaction of HOXD3 with VEGFR was shown using ChIP assays with control (rat IgG) or anti-HOXD3 antibody. (F) qRT-PCR analysis was performed with primers spanning predicted HOXD3 of VEGFR. (G) The expression of VEGFR was analyzed by qRT-PCR after transfection with HOXD3 vector or empty vector in SMMC-7721 cells (*p < 0.05, **p < 0.01).