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. 2018 Feb 5;8:2362. doi: 10.1038/s41598-018-19658-7

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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CANA attenuates the development to hepatocellular carcinoma in WD-fed MC4R-KO mice. The changes in (a) blood glucose levels and (b) body weight during CANA treatment for 52 weeks. n = 8–9. (c) Representative images of livers. Arrows indicate tumors. (d) Tumor numbers and maximum size. (e) Triglyceride content of the liver tissues from non-tumor sites. (f) Sirius red staining of the liver sections and (g) quantification. (h) Serum ALT levels. (i) Expression levels of Myc and Afp genes in the liver tissues from non-tumor (NT) or tumor (T) sites. Original magnification, ×100. Scale bars, 100 μm. *p < 0.05, **p < 0.01 vs MC4R-KO/WD. Statistical analyses were performed using non-paired Student’s t (a,d,e,h and i) or Mann-Whitney (g) test. n = 7–8.