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. 2018 Feb 1;9:136. doi: 10.3389/fimmu.2018.00136

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Copyright © 2018 Spindler and Waschke.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Pemphigus autoantibodies interfere with desmosome turnover. Left panel: a simplified view of the assembly pathway of desmosomes. Desmosomal cadherins and the plaque components desmoplakin (DP), plakophilins (Pkps), as well as the keratins are transported to the plasma membrane by distinct routes and may involve an intermediate complex containing adherens junction proteins. Right panel: Pemphigus autoantibodies interfere with the assembly of nascent desmosomes and promote the disassembly of existing desmosomes. The modulation of desmosome turnover is tied to changes of intracellular-signaling cascades which, for instance, lead to the phosphorylation or cleavage of desmosomal components. Linear arrays represent zones of desmosome disassembly. Split desmosomes may occur if the already-weakened desmosomes are exposed to shear stress.