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. 2018 Feb 1;9:34. doi: 10.3389/fphar.2018.00034

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Copyright © 2018 Brijmohan, Batchu, Majumder, Alghamdi, Thieme, McGaugh, Liu, Advani, Bowskill, Kabir, Geldenhuys, Siddiqi and Advani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transcription factor EB (TFEB) expression is decreased and levels of the adaptor protein p62 are increased in the kidneys of patients with diabetic kidney disease. (A) Real-time PCR for TFEB in formalin-fixed paraffin-embedded nephrectomy tissue from individuals with diabetic kidney disease (diabetes, n = 12) and individuals without diabetes and with normal kidney function (control, n = 12). (B) Immunohistochemistry for TFEB and quantification of cortical TFEB in kidney tissue from individuals with diabetic kidney disease (n = 7) or controls (n = 6). Scale bar = 100 μm. (C) Immunohistochemistry for p62 and quantification of tubule p62 immunostaining in kidney tissue from people with diabetic kidney disease (n = 10) or controls (n = 10). Scale bar = 50 μm. AU = arbitrary units. Values are mean ± SEM. ^∗P < 0.05, ^∗∗P < 0.01.