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. 2018 Feb 5;8:2446. doi: 10.1038/s41598-018-20901-4

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Phenotypic characterization of male TG/Nrf2-Ko animals. (A) Scheme of crossbreeding and PCR genotyping of skeletal muscle specific HSA-UCP1-transgenic mice (TG) with whole body Nrf2-Knockout (Nrf2-Ko) mice to generate TG/Nrf2-Ko animals from different gels processed in parallel. (B) Quadriceps (Quad) muscle (C) liver NAD(P)H quinone dehydrogenase 1 (NQO1) activity as prototypic Nrf2-target and proof of principle for functional ablation of Nrf2 action (n = 7–10). (D) Body mass development from 4 to 24 wks and final body composition at 24 wks of age (E) Relative Quad, interscapular brown adipose tissue (iBAT), epidydimal (eWAT) and subcutaneous white adipose tissue (sWAT) and liver weights (F) Representative H&E histological staining of tibiales anterior (TA) muscle, iBAT, sWAT and liver, bars represent 50 µm. (G) Random fed plasma insulin levels and (H) plasma triacylglycerides, free fatty acids and total cholesterol (n = 5–9). (I) Circulating plasma levels of FGF21 and GDF15 (n = 4–5). All data from 24 wks old male mice. All absolute values are expressed as box-and-whisker plots, relative or normalized data are expressed as means + SEM; **p < 0.01; ***p < 0.001.