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. 2018 Feb 1;10:20. doi: 10.3389/fnagi.2018.00020

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Copyright © 2018 Colini Baldeschi, Pittaluga, Andreola, Rossi, Cozzolino, Nicotera, Sferrazza, Pierimarchi and Serafino.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Atrial natriuretic peptide pre-treatment reverses the neurotoxin-induced changes in β-catenin phosphorylation and degradation and in the expression of DA neuron specific markers and survival factors in SHSY5Ydiff cells. WB (A) and densitometric (B–D) analyses of the expression levels of TH, Nurr1, DJ-1 and phospho-Akt^T308, and total and phosphorylated β-catenin (pβ-catenin^T41/S65), in SHSY5Ydiff cells subjected to 7h and 24h 6-OHDA challenging in absence and in presence of 30 min or 24 h pre-treatment with ANP. In the panel of WB (A), the duration of each treatment is reported above the corresponding lane. Values from densitometric analysis were normalized to β-actin, or vs the total levels of β-catenin or AKT for the phosphorylated forms. ^∗Significance vs untreated control (Ctr); ^#Significance vs 6OH-Dopa: ^∗p < 0.05; ^∗∗p < 0.01; ^∗∗∗p < 0.001; the mean ± SD; n = 3.