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. 2018 Feb 1;12:22. doi: 10.3389/fncel.2018.00022

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Copyright © 2018 Jones, Bernardinelli, Zarruk, Chierzi and Murai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPARC-treated organotypic hippocampal slices have increased synaptic strength which is mediated via GluA1-containing AMPARs. (A) Sample traces of mEPSC recordings from hippocampal neurons of control, SPARC-treated (0.5 μg/ml, 48 h), Phx-433 treated and SPARC and Phx-433 treated organotypic hippocampal slices. (B) Graphs of average mEPSC amplitudes (left) and frequency (right) showing significantly increased mEPSC amplitudes in hippocampal slices treated with SPARC (0.5 μg/ml, 48 h). The increase in mEPSC amplitude was inhibited when slices were also treated with Phx-433, indicating that the change in synaptic strength is mediated via GluA1-containing AMPARs [ANOVA with post hoc Holm–Sidak test: n = 10 for control, n = 9 for SPARC, n = 8 for Ctrl + Phx-433 and n = 8 for SPARC + Phx-433, ^∗∗∗p < 0.001].