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. 2018 Feb 1;12:22. doi: 10.3389/fncel.2018.00022

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Copyright © 2018 Jones, Bernardinelli, Zarruk, Chierzi and Murai.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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SPARC treatment rescues OGD-induced of loss of synaptic GluA1. (A) Representative immunoblots showing total (left panel, ‘crude’) and synaptic (right panel) proteins (GluA1, GluA2, vGlut1, GluN1, and PSD-95) from synaptosome preparations following control, SPARC (0.5 μg/ml, 48 h), OGD and OGD with SPARC treatment of organotypic slices. Slices were treated with SPARC 48 h prior to OGD and during the 48 h reoxygenation period. (B) OGD treatment of organotypic hippocampal slices induced a significant loss of synaptic proteins, however, SPARC treatment was able to rescue synaptic levels of GluA1 and GluN1 but not GluA2 [ANOVA with post hoc Holm–Sidak test (n = 4), ^∗p < 0.05].