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. 2018 Feb 5;8:2418. doi: 10.1038/s41598-018-20215-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regulatory network motifs involving intragenic miRNAs. (а) A self-regulatory negative feedback loop. (b) A self-regulatory positive feedback loop. (c) Representation of a self-regulatory feedback loop in the constructed network of intergenic interactions induced by intragenic miRNAs (note that loops are removed prior to the analysis of the network). (d) A pair of genes mutually targeting each other via their intragenic miRNAs. (e) Representation of miRNA-induced intergenic interactions shown in panel (d) in the constructed network. (f) A three-node sub-network in which each pair of nodes is mutually (bidirectionally) connected.