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. 2018 Feb 5;8:2418. doi: 10.1038/s41598-018-20215-5

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Three-node network motifs overrepresented in the F-network and IS-network in comparison with random graphs (a) generated using a model with a fixed set of out-degrees of vertices; (b) generated with the Erdős–Rényi model; (c) generated using any of these two models.