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. 2018 Feb 1;12:28. doi: 10.3389/fnins.2018.00028

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Copyright © 2018 Sugai, Kato, Koyama, Koike, Kasahara, Konno, Ishihara and Onodera.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A model of transgenic TARDBP expression and a model involving exogenous TDP-43 fragments. (A) Graphic representation of TDP-43 metabolism in cells expressing a TARDBP transgene that lacks a 3'-UTR. (B) Changes in the level of each element over time when exogenous TARDBP mRNA was expressed at a level equivalent to the initial level of the endogenous TARDBP mRNA. (C) The relative amounts of endogenous TDP-43 in the nucleus (vertical axis) and aggregates (area of circle) are shown when exogenous TARDBP expression was increased in a stepwise manner (horizontal axis). (D) The relative amounts of endogenous nuclear TDP-43 (vertical axis) and aggregates (area of the circle) compared with the relative amount of extracellular fragmented TDP-43 (horizontal axis) are shown.