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. 2018 Feb 6;9:443. doi: 10.1038/s41467-018-02885-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Pharmacokinetics. Balb/cJ mice were administered a single IM dose of NDTG or NMDTG (45 mg/kg DTG-eq.) to determine pharmacokinetic (PK) profiles. a Animal weights were monitored for the length of the study to assess animal health. b Blood DTG and MDTG concentrations were analyzed by UPLC-MS/MS. Solid lines indicate [DTG], while the dashed line indicates [MDTG] from NMDTG treatment. Dotted lines indicate the PA-IC₉₀ (64 ng/mL) and four-times the PA-IC₉₀ (256 ng/mL). c–h Tissue DTG concentrations were analyzed by UPLC-MS/MS. (c) Spleen, (d) lymph node, (e) GALT, (f) liver, (g) lung, and (h) kidney DTG levels are shown at days 28 and 56. ****P < 0.0001. Results are shown as the mean ± SEM of at least six biological replicates. Results from c–h were analyzed by two-tailed Student’s t test (for all, n = 6 NDTG, 6 NMDTG, degrees of freedom = 10; c t = 14.4; d t = 16.4; e t = 9.3; f t = 17.3; g t = 30.1; h t = 22.7)