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. 2018 Feb 5;8:2368. doi: 10.1038/s41598-018-19654-x

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Post-injury administration of pifithrin (PFT)-α at 5 h after a traumatic brain injury (TBI) reduced levels of Beclin-1, light chain (LC)3-II and p62 expression in striatal tissues at 24 h. Levels of Beclin-1 (A), LC3 (B) and p62 (C) expression in striatal tissues from the Sham + Veh, Sham + PFT-α, TBI + Veh, and TBI + PFT-α groups were analyzed by Western blotting. Levels of Beclin-1, LC3I, LC3II and p62 expression were normalized to β-actin and then quantified. Data are expressed as the mean ± SD (n = 4 per group). *P < 0.05 and ***P < 0.001 vs. Sham + Veh group; ⁺P < 0.05 and ⁺⁺P < 0.01 vs. TBI + Veh group.