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. 2018 Feb 5;9:500. doi: 10.1038/s41467-018-02863-3

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Model for the regulation of BMI1 on androgen receptor independently of PRC1. Besides its PRC1-dependent role (canonical pathway) as a transcriptional repressor, BMI1 also has a PRC1-independent role (noncanonical pathway) as a transcriptional activator: BMI1 stabilizes AR and activates AR-signaling pathway via competitively inhibiting MDM2-induced ubiquitination and degradation of AR in PCa