Table 1.
Centrality of diseases in diseasomes, calculated as the degree centrality of each disease within diseasomes and average centrality across four diseasomes
| Disease | Gene network degree | Interaction network degree | Symptom network degree | Comorbidity network degree | Average degree |
|---|---|---|---|---|---|
| Stroke | 10 | 10 | 2 | 7 | 7.25 |
| Alzheimer disease | 6 | 9 | 1 | 5 | 5.25 |
| Dementia | 6 | 10 | 3 | 0 | 4.75 |
| Atherosclerosis | 3 | 6 | 0 | 8 | 4.25 |
| Asthma | 3 | 7 | 1 | 5 | 4 |
| Diabetes mellitusa | 6 | 10 | 0 | 0 | 4 |
| Parkinson disease | 3 | 7 | 2 | 4 | 4 |
| Heart Failure | 1 | 4 | 2 | 7 | 3.5 |
| Migraine Disorders | 1 | 7 | 0 | 5 | 3.25 |
| Myocardial Infarction | 4 | 7 | 2 | 0 | 3.25 |
| Hypertension | 1 | 3 | 1 | 7 | 3 |
| Obesity | 2 | 4 | 0 | 6 | 3 |
a Diabetes mellitus type 2