Table 2.
Interactome-based proximity from sGC subunits to various disease phenotypes
| sGC subunita | Stroke | Disease | Zb | p-valuec |
|---|---|---|---|---|
| All | Vision disorders | −3.405 | 0.00033 | |
| Varicose veins | −3.135 | 0.00086 | ||
| Esophageal disease | −3.001 | 0.00134 | ||
| Spinocerebellar ataxias | −2.995 | 0.00137 | ||
| Asthma | −2.787 | 0.00266 | ||
| Head and neck neoplasms | −2.725 | 0.00321 | ||
| * | Stroke | −2.698 | 0.00348 | |
| Retinitis pigmentosa | −2.279 | 0.01132 | ||
| Diabetes mellitus type 2 | −2.122 | 0.01691 | ||
| α-1 | Vision disorders | −3.711 | 0.00010 | |
| Varicose veins | −3.239 | 0.00060 | ||
| Esophageal disease | −2.959 | 0.00154 | ||
| Spinocerebellar ataxias | −2.741 | 0.00307 | ||
| Head and neck neoplasms | −2.529 | 0.00572 | ||
| Asthma | −2.494 | 0.00631 | ||
| * | Stroke | −2.288 | 0.01106 | |
| Retinitis pigmentosa | −1.923 | 0.02727 | ||
| Diabetes mellitus type 2 | −1.778 | 0.037678 | ||
| α-2d | Vision disorders | −2.383 | 0.00859 | |
| Spinocerebellar ataxias | −2.356 | 0.00923 | ||
| * | Stroke | −2.289 | 0.01105 | |
| Varicose veins | −2.240 | 0.01255 | ||
| Esophageal disease | −2.238 | 0.01263 | ||
| Asthma | −2.217 | 0.01330 | ||
| Head and neck neoplasms | −2.127 | 0.01672 | ||
| Retinitis pigmentosa | −2.108 | 0.01751 | ||
| X-linked mental retardation | −2.080 | 0.01874 | ||
| β-1e | Vision disorders | −2.387 | 0.00848 | |
| * | Stroke | −2.339 | 0,00966 | |
| Asthma | −2.291 | 0.01097 | ||
| Varicose veins | −2.270 | 0.01162 | ||
| Spinocerebellar ataxias | −2.266 | 0.01172 | ||
| Head and neck neoplasms | −2.225 | 0.01302 | ||
| Esophageal disease | −2.199 | 0.01394 | ||
| Retinitis pigmentosa | −2.041 | 0.02062 | ||
| Diabetes mellitus type 2 | −1.931 | 0.02671 |
a sGC is an heterodimer requiring both one α and one β subunit
b For each protein and diseases, the proximity quantifies the significance of closeness of the set of proteins to the disease-genes, producing negative z-scores for protein–disease pairs that are closer in the interactome compared to random expectation
c The p-value was calculated using the proximity score (z), corresponding to the probability that a randomly selected protein having the same degree in the interactome as the protein of interest would be at least as close to the disease genes than the observed distance in the interactome
d For stroke (annotated as cerebrovascular disease in MeSH), α2-subunit, which is predominantly expressed in neurons has the third highest score
e The active β1 subunit has the second highest score