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. 2018 Feb 5;9:493. doi: 10.1038/s41467-017-02640-8

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© The Author(s) 2017

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Mathematical model: analysis of the effect of IFNβ pre-stimulation on responses to poly(I:C). a Network diagram. The components of the model which do not influence other components are listed next to the diagram. Blue arrow-headed lines = activation, red hammer-headed lines = inhibition, green arrow-headed lines = positive regulation of transcription. b, c The three-day long stochastic simulations are preceded by 3 × 10⁶ s (~35 days) of stochastic equilibration phase (not shown) rendering different values of model variables at time = 0 for the 5 trajectories shown in each panel. b After 2 days of quiescence, WT MEFs were stimulated with 1 μg/ml poly(I:C) for 1 day. c After 1 day of quiescence, WT MEFs were prestimulated with 1000 U/ml IFNβ for 1 day, followed by 1 day stimulation with 1 μg/ml poly(I:C)