Table 1. CircRNAs potentially involved in cancer and their putative functions.
circBase ID (Alias) | Putative function | Name of the host gene | Type of cancer | Upregulated/downregulated in cancer | References |
---|---|---|---|---|---|
hsa_circ_0004277 | miRNA spongea | WDR37 | AML | Upregulated | 94 |
hsa_circ_0075828 | miRNA spongea | LINC00340 | BCC | Upregulated | 71 |
hsa_circ_0075825 | miRNA spongea | LINC00340 | BCC | Upregulated | 71 |
hsa_circ_0022383 | miRNA spongea | FADS2 | BCC CSCC | Downregulated Downregulated | 71 80 |
hsa_circ_0022392 | miRNA spongea | FADS2 | BCC CSCC | Downregulated Downregulated | 71 80 |
hsa_circ_0041103 | miRNA sponge | TCF25 | Bladder cancer | Upregulated | 73 |
hsa_circ_0002768 | miRNA sponge | MYLK | Bladder cancer | Upregulated | 53 |
Not provided (circ-Foxo3) | Protein scaffolding | FOXO3 | Breast cancer | Downregulated | 47 |
hsa_circ_0008717 | miRNA sponge | ABCB10 | Breast cancer | Upregulated | 76 |
hsa_circ_0001946 (ciRS-7) | miRNA sponge | CDR1AS | CRC CRC Glioma HCC | Upregulated Upregulated Downregulated Upregulated | 77 56 84 85 |
Not provided (hsa_circRNA_104700) | miRNA spongea | PTK2 | CRC | Downregulated | 66 |
hsa_circ_0000069 | Not investigated | STIL | CRC | Upregulated | 60 |
Not provided (circCCDC66) | miRNA sponge | CCDC66 | CRC | Upregulated | 39 |
Not provided (cir-ITCH) | miRNA sponge | ITCH | CRC Lung cancer ESCC HCC | Downregulated Downregulated Downregulated Downregulated | 78 55 54 89 |
hsa_circ_0000523 (circ_006229) | Not investigated | METTL3 | CRC | Downregulated | 77 |
hsa_circ_0001346 | Not investigated | RNF13 | CRC | Downregulated | 77 |
hsa_circ_0001793 | Not investigated | IKBKB | CRC | Upregulated | 77 |
hsa_circ_0070933 | miRNA spongea | LARP1B | CSCC | Upregulated | 80 |
hsa_circ_0070934 | miRNA spongea | LARP1B | CSCC | Upregulated | 80 |
hsa_circ_0067934 | Not investigated | PRKCI | ESCC | Upregulated | 63 |
Not provided (circPVT1) | miRNA sponge | PVT1 | Gastric cancer | Upregulated | 44 |
hsa_circ_0000190 | Not investigated | CNIH4 | Gastric cancer | Downregulated | 59 |
hsa_circ_0000096 | Not investigated | HIAT1 | Gastric cancer | Downregulated | 61 |
hsa_circ_0000140 (hsa_circ_002059) | Not investigated | KIAA0907 | Gastric cancer | Downregulated | 62 |
Not provided (circ_VCAN) | Not investigated | VCAN | Glioma | Upregulated | 83 |
Not provided (cZNF292) | Not investigated | ZNF292 | Glioma | Downregulated | 52 |
hsa_circ_0000594 | miRNA sponge | TTBK2 | Glioma | Upregulated | 50 |
hsa_circ_0001649 | miRNA spongea | SHPRH | HCC | Downregulated | 86 |
hsa_circ_0001727 | miRNA spongea | ZKSCAN1 | HCC | Downregulated | 65 |
hsa_circ_0005075 | miRNA spongea | EIF4G3 | HCC | Upregulated | 87 |
hsa_circ_0000284 (circHIPK3) | miRNA sponge | HIPK3 | HCC | Upregulated | 41 |
hsa_circ_0007874 | miRNA sponge | MTO1 | HCC | Downregulated | 58 |
hsa_circ_0004018 | miRNA spongea | SMYD4 | HCC | Downregulated | 67 |
hsa_circ_0003570 | Not investigated | FAM53B | HCC | Downregulated | 88 |
hsa_circ_0013958 | miRNA sponge | ACP6 | Lung Cancer | Upregulated | 68 |
hsa_circ_0016347 | miRNA sponge | KCNH1 | Osteosarcoma | Upregulated | 69 |
Not provided (circUBAP2) | miRNA sponge | UBAP2 | Osteosarcoma | Upregulated | 51 |
hsa_circ_0013339 | miRNA sponge | SLC30A7 | OSSC | Upregulated | 57 |
Abbreviations: AML, acute myeloid leukemia; BCC, basal cell carcinoma; circRNA, circular RNA; CRC, colorectal carcinoma; CSCC, cutaneous squamous cell carcinoma; ESCC, esophageal squamous cell carcinoma; HCC, hepatocellular carcinoma; miRNA, microRNA; OSCC, oral squamous cell carcinoma.
Not validated experimentally.