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. 2018 Jan 12;50(1):e425. doi: 10.1038/emm.2017.233

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Neuroprotective effect of CD200-positive AMSCs at 1 week after transplantation. (a) CD200 (red) expression merged with DAPI (blue) was significantly higher at 1 week after AMSC transplantation than after control treatment. (b, d) Decreased Iba-1-positive (green) cells merged with DAPI (blue) were detected, particularly in the peri-infarct border, in the AMSC group compared with the control group. (b, e) GFAP-positive cells (green) were also decreased around peri-infarct border, whereas (b, f) NeuN-positive cells (red) were higher in the AMSC group compared with the control group. (c) Schematic diagram of the Iba-1, GFAP and NeuN detection regions. *** P<0.001; ** P<0.01; * P<0.05 for each comparison. Data are expressed as the mean standard error of the mean. (Scale bar=50 μm).