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. 2018 Jan 26;50(1):e433. doi: 10.1038/emm.2017.246

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Copyright © 2018 The Author(s)

This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-nd/4.0/

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Hydrogen-water administration improves GI function and epithelial integrity of irradiated mice. (a and b) Counts of droppings removed from the cage bedding each day from representative cages, n=6 mice per cage. Statistically significant differences are indicated: ***P<0.005; Student’s t-test. (c) Examples of intestinal tract from a total abdominal irradiated mouse and a TAI-exposed mouse with hydrogen-water treatment. (d) The morphology of small intestine in radiation-induced mice treated with normal water or hydrogen-water is shown by H&E staining. (e–g) The expression levels of Glut1, Pgk1 and MDR1 were assessed by qRT-PCR in small intestine tissue from TAI mice without or with hydrogen-water treatment. Statistically significant differences are indicated: ***P<0.005; Student’s t-test.