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. 2018 Jan 26;50(1):e434. doi: 10.1038/emm.2017.247

Figure 7.

Figure 7

RNF138 expression shows a negative correlation with GADD34 expression in GBM patients. (a, b) The expression levels of RNF138 (a) and GADD34 (b) mRNA in tumor tissues of GBM patients were quantified by real-time qRT-PCR. (c) The expression levels of RNF138 and GADD34 protein in tumor tissues of GBM patients were determined by western blotting. (d) Data sets obtained from Oncomine demonstrated that glioblastoma expressed higher RNF138 mRNA levels (fold change=2.708, p=4.38E-5, t-test=10.368) but lower GADD34 mRNA levels (fold change=−1.185, p=0.008, t-test=−2.505) than normal brain tissues. (e) Data sets obtained from Protein Atlas demonstrated the protein levels of RNF138 were moderately expressed but those of GADD34 were rarely expressed in glioma. (f) Schematic diagram illustrating that RNF138-mediated rpS3 ubiquitination is responsible for radioresistance in GBM cells through down-regulation of rpS3/DDIT3-mediated apoptosis.