Fig. 7.

Apoptosis quantification in the heart. a–c Representative images of tissue sections stained with TUNEL (brown), cardiac troponin T (blue) and Safranin O (red) (nonapoptotic nuclei) at 45 days after cell therapy: a control group, b Dox + placebo group and c Dox + CM-mESC group. Quantification of d total apoptotic cells and e apoptotic cardiomyocytes. One-way ANOVA with a Bonferroni post test: **p < 0.01 compared to the control group; #p < 0.05, ##p < 0.01 compared to the Dox + placebo group. Data shown as mean ± standard deviation; n = 3 for each group. Dox doxorubicin, CM-mESC cardiomyocytes derived from mouse embryonic stem cell