Table 3.
Outcomes of study
| Outcomesa | Control | Intervention | Difference (Bootstrapped 95% CI) | ||
|---|---|---|---|---|---|
| n | Mean | n | Mean | ||
| Base Case Analysis (imputed cases)b | |||||
| EQ-5D-5 L and QALY gains | |||||
| EQ-5D-5 L at baseline | 70 | 0.6746 (0.0284) | 78 | 0.6934 (0.0276) | 0.1088 (−0.0489, 0.0916) |
| EQ-5D-5 L at 3 months | 70 | 0.5787 (0.0407) | 78 | 0.6358 (0.0349) | 0.0571 (−0.0556,0.1560) |
| Unadjusted QALYs | 70 | 0.1578 (0.0064) | 78 | 0.1659 (0.0067) | 0.0081 (−0.0090, 0.0265) |
| Adjustedc QALYs | 0.005 (−0.0079, 0.0199) | ||||
| PG-SGA Scores | |||||
| PG-SGA Scores at baseline | 70 | 13.3286 (0.5817) | 78 | 12.1123 (0.4951) | −1.2163 (− 2.6163,0.1793) |
| PG-SGA Scores at 3 months | 70 | 7.3770 (0.4098) | 78 | 5.9136 (0.4054) | −1.4634 (− 2.4801, −0.1896) |
| Unadjusted improvement in PG-SGA Scoresd | 70 | 5.9516 (0.6594) | 78 | 6.1987 (0.5547) | 0.2471 (−1.4931, 1.8661) |
| Adjustedc improvement in PG-SGA Scoresd | 1.3238 (0.0240, 2.3858) | ||||
| Inpatient stay | |||||
| LOS in days | 69 | 9.9 (7.2) | 71 | 6.9 (5.3) | 3.0 (0.9, 5.1) |
| Sensitivity analysis (complete cases)e | |||||
| EQ-5D-5 L and QALY gains | |||||
| EQ-5D-5 L at baseline | 69 | 0.6736 (0.0290) | 77 | 0.6926 (0.0272) | 0.0189 (−0.0537, 0.1003) |
| EQ-5D-5 L at 3 months | 60 | 0.5672 (0.0487) | 69 | 0.6360 (0.0407) | 0.0688 (−0.0553, 0.2043) |
| Unadjusted QALYs | 59 | (0.1553 (0.0076) | 69 | 0.1658 (0.0075) | 0.0105 (−0.0096, 0.0291) |
| Adjustedc QALYs | 0.0060 (−0.0086, 0.0216) | ||||
| PG-SGA Scores | |||||
| PG-SGA Scores at baseline | 69 | 13.3478 (0.5848) | 74 | 12.0946 (0.5240) | −1.2532 (−2.9491, 0.2727) |
| PG-SGA Scores at 3 months | 46 | 6.9783 (0.6167) | 57 | 5.8070 (0.5185) | −1.712 (−2.7446, 0.3698) |
| Unadjusted improvement in PG-SGA Scoresd | 46 | 6.1739 (0.8876) | 57 | 5.8596 (0.7081) | −0.3143 (− 2.4223, 1.8485) |
| Adjustedc improvement in PG-SGA Scoresd | 0.9849 (−0.5601, 2.5912) | ||||
aEQ-5D-5 L EuroQoL 5 Dimensions 5 Levels, QALY Quality Adjusted Life Years, PG-SGA Patient Generated Subjective Global Assessment, LOS Length of Hospital Stay
bMultiply imputed values. Multiple imputations carried out to account for up to 12% of the EQ-5D-5 L utility scores (2 or 1% of baseline and 19 or 1% of 3-month EQ-5D-5 L scores)
cThese scores have been adjusted for baseline differences
dThese PG-SGA scores were reverse scored so that a positive score reflects an improvement in nutrition status
eTrial participants with complete information on baseline and 3-month outcomes