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. 2018 Feb 5;16:6. doi: 10.1186/s12964-018-0217-2

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 1 — Low-dose DOX-induced drug resistance in hepatoma SMMC-7721 cells. a SMMC-7721 and SMMC-7721/DOX cell configuration. b Growth curves of SMMC-7721 and SMMC-7721/DOX cells c Change in cell viability induced by different concentrations of DOX. d Immunofluorescence staining for P-gp with polyclonal mouse anti-P-gp minigene (green). Nuclear DNA was stained with DAPI (blue). DOX showed red fluorescence. Merge, maximum projection