Table 3.
Allele frequencies and Hardy–Weinberg estimations of SNPs in the study population
| Polymorphisms RNASE3 | MAF (A1 frequency) | HWE* p value |
Allele A1 African (NCBI db) | Allele A1 European (NCBI db) | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Location referred to ATG meth start | NCBI dbSNP number | A1 | A2 | Amino acid change | SM | UM | CTR | Global population | |||
| Promoter −550G/A | rs2284954 | A | G | – | 0.14 | 0.11 | 0.16 | 0.14 | 0.07 | 0.23 | 0.70 |
| Promoter −399T/C* | rs147413155 | C | T | – | 0.08 | 0.03 | 0.03 | 0.04 | 0.02 | 0.04 | 0.00 |
| Promoter −38C/A** | rs2233859 | A | C | – | 0.02 | 0.02 | 0.05 | 0.03 | 0.16 | 0.03 | 0.42 |
| Coding +371_G/C | rs2073342 | G | C | Arg/Threo | 0.46 | 0.4 | 0.34 | 0.41 | 0.08 | 0.37 | 0.71 |
| 3′utr +499_G/C | rs2233860 | C | G | – | 0.14 | 0.25 | 0.23 | 0.21 | 0.15 | 0.23 | 0.18 |
| 3′utr +577_A/T | rs8019343 | T | A | – | 0.23 | 0.19 | 0.18 | 0.21 | 0.83 | 0.83 | 0.001 |
SM Severe malaria, UM Uncomplicated Malaria, CTR Control group HWEp Hardy–Weinberg in global group, p promoter region, c coding region, u untranslated region
* Deviation from Hardy–Weinberg, with values p < 0.012 (corrected threshold)
** Minor Allele frequency in Global population (MAF) < 0.05