Table 6.
Detailed association of RNASE3 +499G/C genotypes with malaria severity
| Genotypes | Malaria Groups | Nominal p value for Statistical test | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| SM | UM | CTR | UM vs CTR | SM vs CTR | SM vs UM | SM vs CTR + UM | |||||
| p | OR 95 %CI | p | OR 95 %CI | p | OR 95 %CI | p | OR 95 %CI | ||||
| GG genotype as reference | |||||||||||
| GG | 70 | 41 | 31 | – | 1 | – | 1 | – | 1 | – | 1 |
| GC | 18 | 27 | 21 | 0.670 | 1.21 (0.49–2.08) | 0.014 | 0.33 (0.14–1.02) | 0.006 | 0.32 (0.14–1.82) | 0.002 | 0.34 (0.17–0.98) |
| CC | 4 | 7 | 2 | 0.210 | 3.15 (0.53–4.02) | 0.365 | 0.37 (0.05–1.01) | 0.013 | 0.11 (0.02–0.99) | 0.040 | 0.18 (0.04–1.01) |
| CC genotype as reference | |||||||||||
| CC | – | – | – | – | 1 | – | 1 | – | 1 | – | 1 |
| GC | – | – | – | 0.305 | 0.38 (0.06–0.98) | 0.921 | 0.89 (0.10–1.01) | 0.246 | 2.86 (0.48–3.25) | 0.480 | 1.82 (0.34–2.35) |
This table gives RNASE3 u + 499G/C association analysis between groups. Significant p values are in italic. RNASE3 +499 GC and 499 CC genotypes induced significant association with severity. Logistic regression analysis were performed using plink analysis software. All the values OR were obtained with 95% CI