Table 13.
Biochemical parameters of the rats in sub-acute oral toxicity test
| Biochemical parameters | Groups | P value | ||||
|---|---|---|---|---|---|---|
| Sex | Control | DC 500 mg/kg | DC 1000 mg/kg | DC 1500 mg/kg | ||
| Urea (mmol/L) | M | 3.76 ± 0.59 | 3.92 ± 0.34 | 4.14 ± 0.38 | 4.18 ± 0.51 | 0.466 |
| F | 3.90 ± 0.74 | 4.06 ± 0.44 | 3.97 ± 0.69 | 4.16 ± 1.24 | 0.963 | |
| Creatinine (umol/L) | M | 24.20 ± 4.15 | 24.00 ± 2.55 | 23.60 ± 6.91 | 27.20 ± 4.15 | 0.615 |
| F | 28.60 ± 3.05 | 28.40 ± 2.70 | 27.40 ± 2.70 | 28.80 ± 1.92 | 0.839 | |
| Albumin (g/L) | M | 35.00 ± 2.24 | 34.60 ± 1.14 | 36.20 ± 5.26 | 34.60 ± 1.67 | 0.817 |
| F | 35.00 ± 1.58 | 34.60 ± 2.40 | 36.20 ± 2.17 | 34.00 ± 2.55 | 0.470 | |
| Globulin (g/L) | M | 20.60 ± 1.14 | 21.00 ± 1.58 | 21.20 ± 1.48 | 21.20 ± 1.30 | 0.890 |
| F | 22.40 ± 1.14 | 21.80 ± 1.10 | 22.80 ± 1.30 | 21.20 ± 1.48 | 0.245 | |
| Total bilirubin (umol/L) | M | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | – |
| F | 2.00 ± 0.00 | 2.00 ± 0.00 | 2.00 ± 0.00 | 2.00 ± 0.00 | – | |
| Conjugate bilirubin (umol/L) | M | 1.40 ± 1.14 | 1.00 ± 0.00 | 0.40 ± 0.55 | 1.00 ± 1.22 | 0.379 |
| F | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | 1.00 ± 0.00 | – | |
| ALP (U/L) | M | 216.20 ± 16.99 | 218.40 ± 12.70 | 222.40 ± 18.51 | 236.40 ± 12.74 | 0.203 |
| F | 204.20 ± 14.64 | 210.80 ± 29.52 | 209.60 ± 23.70 | 197.60 ± 16.33 | 0.769 | |
| ALT (U/L) | M | 29.60 ± 3.29 | 29.40 ± 1.52 | 29.60 ± 2.30 | 32.00 ± 2.83 | 0.356 |
| F | 23.40 ± 3.21 | 23.60 ± 3.05 | 25.40 ± 3.36 | 26.80 ± 1.64 | 0.243 | |
| AST (U/L) | M | 104.80 ± 6.69 | 106.00 ± 3.94 | 105.40 ± 5.55 | 109.00 ± 4.95 | 0.623 |
| F | 99.60 ± 7.40 | 103 ± 2.30 | 103.60 ± 3.44 | 104.60 ± 2.41 | 0.320 | |
Values expressed as a mean ± standard deviation, n = 5. Sex (male, M and female, F)
*p-value less than 0.05, (p < 0.05) significant value