Table 7.

(A and B) Water intake (ml) of rats in the acute and sub-acute oral toxicity tests

A		Acute oral toxicity
	Sex	Control	DC 300 mg/kg	DC 2000 mg/kg		P value
Week 1	F (n = 3)	102.56 ± 1.27	104.03 ± 1.78	104.34 ± 2.12		0.157
Week 2	F (n = 3)	102.54 ± 0.97	104.00 ± 1.77	103.93 ± 2.01		0.199
B		Sub-acute oral toxicity
	Sex	Control	DC 500 mg/kg	DC 1000 mg/kg	DC 1500 mg/kg	P value
Week 1	M (n = 5)	123.18 ± 1.39	128.09 ± 2.34	128.03 ± 1.91	127.40 ± 2.11	0.000*
	F (n = 5)	122.39 ± 0.42	125.51 ± 0.50	125.48 ± 0.37	125.46 ± 0.53	0.000*
Week 2	M (n = 5)	124.06 ± 1.17	127.31 ± 1.50	127.44 ± 1.48	127.97 ± 1.85	0.000*
	F (n = 5)	123.33 ± 0.55	125.68 ± 0.45	125.99 ± 0.41	125.87 ± 0.41	0.000*
Week 3	M (n = 5)	125.23 ± 0.96	127.99 ± 1.33	127.98 ± 1.80	127.86 ± 1.69	0.004*
	F (n = 5)	124.44 ± 0.49	127.29 ± 0.66	127.12 ± 0.61	127.16 ± 0.77	0.000*
Week 4	M (n = 5)	125.89 ± 0.78	128.29 ± 1.95	128.54 ± 1.22	128.34 ± 1.61	0.007*
	F (n = 5)	124.99 ± 0.50	127.28 ± 0.86	127.36 ± 0.63	127.56 ± 0.61	0.000*

Values expressed as a mean ± standard deviation. Sex (male, M and female, F)

*p-value less than 0.05, (p < 0.05) significant value. Numbers in bold indicate a statistically significant difference