Table 2.
Authors | Study Subjects (Years of Observation) | Health Outcames | Reported Findings |
---|---|---|---|
Senior and Mazza [1] | 250,000 residents in “Triangle of Death” area (2002) | Cancer mortality | All cancers SDR * = 321.7 (M) vs. regional rate 305.6 Liver SDR = 35.9 (M) vs. regional rate 15.0 Larynx SDR = 12.8 (M) vs. regional rate 8.7 Bladder SDR = 29.3 (M) vs. regional rate 21.7 Colorectal SDR = 29 (F) vs. regional rate 26.4 Leukemia and lymphoma SDR = 28.2 vs. regional rate 17.9 (M); 18.7 vs. regional rate 16.1 (F) |
Altavista et al. [19] | 150,000 residents in 3 municipalities of Naples (Giugliano, Qualiano and Villaricca) (1986–2000) | Cancer mortality and congenital malformations | All cancers SMR = 107.23 (M) − 111.08 (F) Liver SMR = 181.13 (F) Lung SMR = 121.85 (M) − 176.94 (F) Larynx SMR = 211.85 (M) Bladder SMR = 130.12 (M) Stomach SMR = 56.1 (M) |
Triassi et al. (review) [10] | 250,000 residents in “Triangle of Death” area (2002) | Cancer mortality | In the “Triangle of Death” area, an increased in standardized death rate (vs. regional expected rate) for all cancers (SDR = 321.7 vs. 305.6 per 100,000 males) was reported, along with increases in standardized mortality rates for specific tumors such as liver, larynx, bladder, colorectal cancer and leukemia/lymphoma, especially in male population |
Comba et al. [20] | About 4 million residents in 196 municipalities of Caserta and Naples (1994–2001) | Cancer mortality and congenital malformations | A statistically significant excess of cancer mortality was found in the provinces of Naples (+8.7% in men and +9.2% in women) and Caserta (+2.3% but only in males). In particular, significant excesses of liver, lung, bladder, stomach, non-Hodgkin lymphoma and kidney cancer were reported. Malformations: total, cardiovascular and urogenital |
Martuzzi et al. [21] | About 4 million residents in 196 municipalities of Caserta and Naples (1994–2001) | Cancer mortality and congenital malformations | An excess of cancer mortality was reported to be associated with measures of environmental contamination. Statistically significant excess relative risks in high-index (exposed) compared with low-index (unexposed) municipalities were found for all-cause mortality (both sexes), for all cancers (both sexes), and stomach and lung cancer (in men) |
Fazzo et al. [22] | About 4 million residents in 196 municipalities of Caserta and Naples (1994–2001) | Cancer incidence and congenital malformations | Clusters of significant increases of cancer incidence were detected for liver, lung, bladder, stomach and kidney cancer. Malformations: total, cardiovascular, urogenital and limb |
Fazzo et al. [23] | About 5 million residents in 35 municipalities of Naples Province (1997–2005) | Cancer incidence and congenital malformations | Clusters of increased cancer incidence during the years 1997–2005 were detected in the total population for liver and lung cancer, leukemia and soft tissue sarcomas |
Comba et al. [24] | Residents in 55 municipalities of the “Land of Fires” (2007–2010) | Cancer incidence and mortality causes | Excesses of incidence, hospitalization and mortality rates were reported in the Province of Naples for stomach, liver, lung, bladder, pancreatic, laryngeal, kidney, breast cancer, and non-Hodgkin’s lymphoma. |
Pirastu et al. [7] | Residents in 55 municipalities of the “Land of Fires” (2007–2010) | Cancer incidence and mortality causes | In the Caserta province, excesses of mortality and hospitalization rates were reported for stomach, liver, lung, bladder, laryngeal cancer and leukemia. |
Barba et al. (review) [9] | Residents in polluted areas of the Campania region | Cancer mortality and congenital malformations | Significant increase in cancer mortality and malformation occurrence in specific areas of the Campania region, where improper waste management and illegal waste trafficking have been repeatedly documented, was reported |
M = male; F = female. SDR: standardized death rate; * Per 100,000 population.