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. 2018 Jan 19;15(1):160. doi: 10.3390/ijerph15010160

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Mechanistic framework explaining how inhaled air pollutants disrupt mood related behavior. After PM_2.5 exposure, the decreased expression level of GR in hippocampus result in the increased secreting of glucocorticoid, which activated inflammatory response of hippocampus, and thus provoked the mood-related behaviors disorder. PM: particulate matter; GR: glucocorticoid receptors; GC: glucocorticoid; HPA: hypothalamic-pituitary-adrenal; CRH: corticotropin-releasing hormone; ACTH: adrenocorticotropic hormone.