Table 3.
Multivariate Cox regression analysis for recurrence and distant metastasis based on 244 cases with complete data for all variables
| Univariate | Multivariatea | |||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| RFS | ||||||
| Breslow | 1.3 | 1.2–1.3 | < 0.001 | 1.2 | 1.1–1.3 | < 0.001 |
| Mitotic rate ≥ 1/mm2 | 3.3 | 1.9–5.7 | < 0.001 | 0.9 | 0.5–1.7 | 0.8 |
| Ulceration present | 4.5 | 3.2–6.5 | < 0.001 | 1.4 | 0.8–2.2 | 0.2 |
| SLN positive | 3.5 | 2.4–5.1 | < 0.001 | 2.5 | 1.6–4.0 | < 0.001 |
| GEP Class 2 | 5.4 | 3.7–7.7 | < 0.001 | 2.1 | 1.3–3.4 | 0.003 |
| DMFS | ||||||
| Breslow | 1.4 | 1.3–1.5 | < 0.001 | 1.3 | 1.2–1.4 | < 0.001 |
| Mitotic rate ≥ 1/mm2 | 3.9 | 2.0–7.5 | < 0.001 | 0.9 | 0.5–2.0 | 0.9 |
| Ulceration present | 4.8 | 3.2–7.2 | < 0.001 | 1.2 | 0.7–2.1 | 0.5 |
| SLN positive | 3.8 | 2.5–5.9 | < 0.001 | 3.0 | 1.7–5.2 | < 0.001 |
| GEP Class 2 | 6.6 | 4.3–10.2 | < 0.001 | 2.7 | 1.5–4.8 | 0.002 |
CI confidence interval, DMFS distant metastasis-free survival, GEP gene expression profile, RFS recurrence-free survival
aThe multivariate Cox regression model includes data from 244 of 523 cases with complete information for Breslow thickness, mitotic rate, ulceration, SLN status and GEP class