Fig. 1.

Treatment with Terminalia macroptera improves the outcome of Plasmodium berghei ANKA and P. chabaudi chabaudi infections. Swiss mice received vehicle (water), or extracts of leaves of Terminalia macroptera (TML, 100 mg/kg), or extracts of roots of Terminalia macroptera (TMR, 100 mg/kg), or chloroquine (CQ, 25 mg/kg) 2 h following intraperitoneal infection (10⁶ Plasmodium/mice) from day 0 to day 4. a, b Parasite densities were measured daily. Parasite densities were compared according to treatment received, **P < 0.005 or ***P < 0.0005 compared CQ treatment to vehicle, ^##P < 0.005 compared TMF to vehicle, ^§§P < 0.005 compared TMR to vehicle. c, d survival were measured daily. Survival were compared according to treatment received at D9 for P. berghei and at D11 for P. c. chabaudi, **P < 0.005 compared CQ treatment to vehicle, ^#P < 0.05 compared TMF to vehicle, ^§P < 0.05 compared TMR to vehicle. ns not significant