Table 5.

Children’s Oncology Group neuroblastoma (NB) risk stratification system²⁸

Children’s Oncology Group NB risk stratification system
INSS* stage	Age	MYCN status	Shimada	DNA index	Risk group
1	0–21 years	Any	Any	Any	Low
2A/2B	<365 days	Any	Any	Any	Low
	≥365 days–21 years	Normal	Any	–	Low
	≥365 days–21 years	Amplified	Favorable	–	Low
	≥365 days–21 years	Amplified	Unfavorable	–	High
3	<365 days	Normal	Any	Any	Intermediate
	<365 days	Amplified	Any	Any	High
	≥365 days–21 years	Normal	Favorable	–	Intermediate
	≥365 days–21 years	Normal	Unfavorable	–	High
	≥365 days–21 years	Amplified	Any	–	High
4	<365 days	Normal	Any	Any	Intermediate
	<365 days	Amplified	Any	Any	High
	≥365 days–21 years	Any	Any	–	High
4S	<365 days	Normal	Favorable	>1	Low
	<365 days	Normal	Any	=1	Intermediate
	<365 days	Normal	Unfavorable	Any	Intermediate
	<365 days	Amplified	Any	Any	High

*INSS, International Neuroblastoma Staging System