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Higher pI values of CDR-L3 correlates with higher affinity to FcRn. Plotting the steady-state KD vs. pI of variable regions and CDR-L3 for a subset of IgG molecules from panel 5 that differ by only one amino acid residue in CDR-L3 (mAb-25, 26, 27, 38 and 42) demonstrated a strong correlation between higher pI value and higher affinity to FcRn for variable regions (r =−0.99) and CDR-L3 (r =−0.91).
