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. 2017 Oct 24;10(1):104–117. doi: 10.1080/19420862.2017.1384892

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — MEDI7814 neutralizes C5a and C5adesArg responses in vitro. Representative results showing that MEDI7814 (▴) neutralizes calcium mobilisation in HEK 293 expressing human C5aR1 receptor and Gα16 using (A) 100 pM human C5a, (B) 400 pM human C5adesArg. Data points represent the mean of duplicate wells ± standard deviation. (C) MEDI7814 neutralizes 2 nM human C5a induced chemotaxis of human neutrophils. Data points represent the mean of duplicate wells ± standard deviation. MEDI7814 IC₅₀ values were not determined for A, B and C as the affinity of MEDI7814 exceeds the concentrations of C5a/C5adesArg in these assays, n = 2. No inhibition of responses were observed with the isotype matched irrelevant control antibody (▪).