Table 1. Subject demographics of participating CREAM study groups.
| Study | Ancestry | N (cases/controls) | %Female |
Age (years) |
Corneal astigmatism (D) |
|
|---|---|---|---|---|---|---|
| Mean (SD) | Median (IQR) | Range | ||||
| ALSPAC |
European |
2279(985/1294) |
53.1 |
15.5 (0.3) |
0.683 (0.469–0.959) |
0.000–5.680 |
| BMES |
European |
1238(720/518) |
41.8 |
73.3 (7.6) |
0.863 (0.565–1.295) |
0.155–8.615 |
| EPIC |
European |
857(456/401) |
58.5 |
68.7 (7.4) |
0.780 (0.527–1.152) |
0.075–3.997 |
| FITSA |
European |
127(62/65) |
100 |
67.9 (3.1) |
0.733 (0.530–1.033) |
0.270–2.020 |
| GenerationR |
European |
2071(981/1090) |
49.9 |
6.09 (0.4) |
0.725 (0.480–0.995) |
0.000–3.370 |
| GHS 11 |
European |
2398(1003/1395) |
48.7 |
55.9 (10.8) |
0.65 (0.400–0.950) |
0.050–4.350 |
| GHS 21 |
European |
851(383/468) |
50.9 |
55.1 (10.8) |
0.65 (0.450–1.000) |
0.050–3.800 |
| RAINE |
European |
1028(407/621) |
50.9 |
20.0 (0.4) |
0.649 (0.445–0.905) |
0.280–2.440 |
| Rotterdam-I |
European |
5537(2064/3473) |
59.3 |
69.5 (9.2) |
0.601 (0.334–1.007) |
0.000–9.663 |
| Rotterdam-II |
European |
1982(633/1349) |
53.8 |
64.8 (8.0) |
0.539 (0.294–0.884) |
0.000–6.789 |
| Rotterdam-III |
European |
2925(1180/1745) |
56.2 |
57 (6.9) |
0.618 (0.356–1.019) |
0.000–4.869 |
| OGP-A2 |
European |
92(37/55) |
44.6 |
16.0 (4.5) |
0.682 (0.512–0.942) |
0.185–3.070 |
| OGP-B2 |
European |
446(181/265) |
43.7 |
50.6 (15.4) |
0.650 (0.430–0.970) |
0.130–4.240 |
| TwinsUK |
European |
419(201/218) |
92.7 |
64 (10.5) |
0.729 (0.476–1.105) |
0.000–5.432 |
| BES-610K3 |
Asian |
553 (240/313) |
65.6 |
62.1 (8.4) |
0.666 (0.407–1.056) |
0.000–3.620 |
| BES-OmniE3 |
Asian |
469 (208/261) |
60.1 |
64.7 (9.5) |
0.676 (0.429–1.016) |
0.000–5.082 |
| SCES-610K3 |
Asian |
1745 (787/958) |
48.7 |
57.6 (9.0) |
0.703 (0.476–1.060) |
0.109–5.868 |
| SCES-OmniE3 |
Asian |
545 (257/288) |
48.6 |
59.2 (8.8) |
0.723 (0.470–1.065) |
0.117–5.404 |
| SCORM |
Asian |
947 (768/179) |
48.6 |
10.8 (0.8) |
1.205 (0.851–1.624) |
0.138–3.911 |
| SIMES |
Asian |
1778 (750/1028) |
51.7 |
59.5 (10.8) |
0.662 (0.432–1.016) |
0.078–5.618 |
| SINDI |
Asian |
2261 (814/1447) |
48.6 |
56.5 (9.1) |
0.614 (0.411–0.912) |
0.115–4.727 |
| STARS | Asian | 822 (525/297) | 50.0 | 38.5 (5.3) | 1.000 (0.625–1.380) | 0.125–3.875 |
1Association tests were undertaken separately for samples recruited in different waves. 2Association tests were undertaken separately for different age strata (stratum A, age >3 and <25 years; stratum B, age ≥25 years). 3Association tests were undertaken separately for samples genotyped on different platforms.