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. 2017 Aug 17;39(2):230–242. doi: 10.1038/aps.2017.63

Figure 1.

Figure 1

QOA-8a suppressed the formation of osteoclasts and stimulated differentiation of osteoblasts. (A) Chemical structure of QOA-8a. (B) Representative TRAP staining in cells; Primary bone marrow-derived macrophages (BMMs) incubated on vehicle (DMSO) or with QOA-8a (0.01, 0.05, 0.5, 2, and 10 μmol/L) in the presence of M-CSF (30 ng/mL) and RANKL (50 ng/mL) for 5 d. Mean±SD. n=6. TRAP+ osteoclast number at control group was 297 (×100). (C) Effects of QOA-8a on the ALP activity in mouse calvarial osteoblastic cell line MC3T3-E1. ALP in aliquots of supernatants (left) and cell lysates (right) were measured by an ALP activity kit, respectively. Mean±SD. n=3. *P<0.05, **P<0.01.