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. 2017 Aug 17;39(2):230–242. doi: 10.1038/aps.2017.63

Figure 4.

Figure 4

QOA-8a leads to an increase in trabecular microarchitecture. OVX rats were left untreated for 8 weeks, then treated orally with vehicle or the indicated dose of QOA-8a and AS (1 mg·kg−1·d−1, orally) for 8 weeks. Mean±SD. n=8. *P<0.05, **P<0.01 vs sham group. #P<0.05, ##P<0.01 vs OVX group. (A) The change of BMD between OVX groups and sham group, measured by DXA after surgical procedure, before treated with QOA-8a. (B) Body weight of OVX groups and sham group after the surgical procedure. (C) Uterine wet weight of OVX groups and sham group after euthanized. (D) The H&E-stained uterine sections (×100), from the different OVX-QOA-8a groups, OVX-AS group and OVX-vehicle groups. (E, F, G) Bone morphometric analysis of right proximal femurs from sham and OVX rats. BV/TV, bone volume/total volume (E); Tb.Th, trabecular bone thickness (F); Tb.Sp, trabecular bone separation (G). (H) Microstructural analysis of trabecular areas of right proximal femurs measured by μCT.