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. 2017 Aug 17;39(2):230–242. doi: 10.1038/aps.2017.63

Figure 5.

Figure 5

QOA-8a increases cortical and cancellous bone mineral densities. The 8 weeks old rats were treated with sham-operation or ovariectomy, and administered with either vehicle, a relatively dose of AS (1 mg·kg−1·d−1, orally) or increasing amounts of QOA-8a (1 or 5 mg·kg−1·d−1, orally). (A) Body weight of OVX groups and sham group after the surgical procedure. (B) Uterine wet weight of OVX groups and sham group after euthanized. (C) The total bone mineral density (T.BMD) of right proximal femurs. (D) Cortical bone mineral densities (Co.BMD) in the right proximal femurs. (E) Cancellous bone mineral densities (Ca.BMD) in the right proximal femurs. ELISA assay for CTX-1 (F), N-MID-OT (G). (H) The endosteal and periosteal circumference at the left femoral shaft. (I) The cortical thickness at the left femoral shaft. Mean±SD. n=10. *P<0.05, **P<0.01 vs sham group. #P<0.05, ##P<0.01 vs OVX group.