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. 2017 Sep 21;39(2):205–212. doi: 10.1038/aps.2017.85

Table 4. The predicted protein targets for aspirin and cilostazol using HTDocking Program (Docking Score represents −logKd).

Protein Docking score Drug name Gene name    
Prostaglandin G/H synthase 1 8.1 Aspirin COX1    
HLA class I histocompatibility antigen, B-39 alpha chain 7.8 Aspirin HLA-B    
Deoxyribonuclease-1-like 1 7.6 Aspirin DNASE1L1    
Cytochrome P450 1A2 7.5 Aspirin CYP1A2    
Heparanase 7.3 Aspirin HPSE    
Serum albumin 7.2 Aspirin ALB    
Ephrin type-A receptor 8 7.2 Aspirin EPHA8    
Heat shock cognate 71 kDa protein 7.1 Aspirin HSPA8    
Proteinase-activated receptor 1 (PAR1) 7.0 Aspirin F2R    
P2X purinoceptor 4 (P2X4) 6.9 Aspirin P2RX4    
Angiotensin II type-2 (AT2) receptor 6.8 Aspirin AGTR2    
Prostaglandin G/H synthase 2 6.7 Aspirin COX2    
Cathepsin G 6.6 Aspirin CTSG    
Angiotensin-converting enzyme 6.5 Aspirin ACE    
P2Y purinoceptor 1 (P2Y1) 11.8 Cilostazol P2RY1    
Heparanase 11.5 Cilostazol HPSE    
Ephrin type-A receptor 8 11.1 Cilostazol EPHA8    
Cathepsin G 11.0 Cilostazol CTSG    
Serum albumin 10.9 Cilostazol ALB    
Heat shock cognate 71 kDa protein 10.9 Cilostazol HSPA8    
Angiotensin II type-2 (AT2) receptor 10.9 Cilostazol AGTR2    
P2X purinoceptor 4 (P2X4) 10.8 Cilostazol P2RX4    
Angiotensin-converting enzyme 10.6 Cilostazol ACE    
Angiotensin II Type-1 (AT1) receptor 10.1 Cilostazol AGTR1    
cGMP-inhibited 3′,5′-cyclic phosphodiesterase A 9.8 Cilostazol PDE3A    
Proteinase-activated receptor 4 (PAR4) 9.7 Cilostazol F2RL3    
P2Y purinoceptor 12 (P2Y12) 9.4 Cilostazol P2RY12