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. 2017 Sep 14;39(2):275–285. doi: 10.1038/aps.2017.90

Table 2. Mean values for the pharmacokinetic parameters of active metabolite (dl-NBP) following intravenous administration of dl-PHPB and dl-NBP in Beagle dogs and SD rats (n=6, 3/sex).

		Beagle dogs				SD rats
		dl-PHPB			dl-NBP	dl-PHPB			dl-NBP
		2 mg/kg	4 mg/kg	8 mg/kg	6.2 mg/kg	5 mg/kg	10 mg/kg	20 mg/kg	15.6 mg/kg
A	μg/mL	28.05	10.05	25.37	16.27	15.74	29.59	47.33	44.73
α	min⁻¹	1.05	0.22	0.15	0.11	0.34	0.16	0.16	0.20
B	μg/mL	0.80	4.64	1.02	3.63	4.47	1.54	1.47	1.89
β	min⁻¹	0.07	0.06	0.02	0.05	0.06	0.02	0.02	0.02
V_(c)	L/kg	0.69	1.36	0.76	1.05	0.62	0.80	1.03	1.05
t_(1/2)α	min	0.66	3.19	4.75	6.34	2.04	4.31	4.33	3.52
t_(1/2)β	min	10.49	11.39	31.29	14.44	11.96	33.40	44.76	43.95
K₂₁	min⁻¹	0.09	0.11	0.03	0.06	0.12	0.03	0.02	0.02
K₁₀	min⁻¹	0.75	0.12	0.12	0.09	0.16	0.12	0.13	0.13
K₁₂	min⁻¹	0.28	0.05	0.02	0.01	0.11	0.03	0.03	0.06
AUC	μg·min·mL⁻¹	38.67	122.50	219.59	224.41	123.48	258.28	390.79	347.30
CL	L·kg⁻¹·min⁻¹	0.52	0.17	0.09	0.08	0.10	0.10	0.13	0.15