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. Author manuscript; available in PMC: 2018 Feb 6.
Published in final edited form as: Toxicol Lett. 2017 Jul 4;278:30–37. doi: 10.1016/j.toxlet.2017.07.007

Figure 5. Connexin hemichannel inhibition differentially affects serum cytokine levels in APAP-induced hepatotoxicity.

Figure 5

Mice (n = 6-8 per group and per time point) were injected 300 mg/kg APAP followed by administration of 10 mg/kg TAT-Gap24, 10 mg/kg TAT-Gap19, a combination of both or saline (SAL) 1.5 hour later. Sampling was performed 6 and 24 hours after APAP overdosing. ELISA analysis of serum samples was performed to detect (A) IL-1β, (B) TNFα, (C) IL-6 and (D) IL-10. Data are expressed as means ± SEM, with *p < 0.05 compared to APAP followed by SAL administration.