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MRL-436-resistant mutants: sequences and properties
| amino acid substitution | number of isolates | resistance level (MIC/MICwild-type)a | |
|---|---|---|---|
|
| |||
| MRL-436 | Rif | ||
| RpoC (RNAP β′ subunit) | |||
| D622G | 1 | >32 | 1 |
| RpoZ (RNAP ω subunit) | |||
| Δ13–91 (frameshift) | 1 | >32 | 1 |
| Δ21–91 (frameshift) | 1 | >32 | 1 |
| Δ23–91 (frameshift) | 1 | >32 | 1 |
| Δ24–91 (frameshift) | 1 | >32 | 1 |
| Δ35–91 (frameshift) | 1 | >32 | 1 |
| Δ1–91 (deletion) | NA | >32 | 1 |
MRL-436 MICwild-type = 2 μg/ml
