TABLE 3.

Multivariate Cox Proportional Hazard Models

Characteristic	HR (95 % CI)	P
Overall Survival
Smad4 loss tumor*	1.27 (0.84–1.91)	0.26
Positive surgical margins	2.03 (1.33–3.08)	0.001
Histologic grade ¾	1.42 (0.94–2.14)	0.09
Lymph node ratio	1.46 (1.01–2.10)	0.04
5-FU based CRT	0.66 (0.34–1.27)	0.21
Tumor size (cm)	1.22 (1.04–1.44)	0.02
Disease free survival		0.47
Smad4 loss tumor*	1.15 (0.79–1.68)	0.007
Positive surgical margins	1.75 (1.17–2.61)	0.01
Histologic grade 3/4	1.61 (1.10–2.35)	0.003
Lymph node ratio	2.98 (1.44–6.18)	0.11
5-FU based CRT	0.59 (0.30–1.13)	0.01

^*By immunolabeling

5-FU indicates 5 Fluorouracil; CRT – chemoradiation therapy