Table 1. Change in long chain acylcarnitine profiles after loss of cardiac KLF15 expression.
| Diet | Normal chow | Normal chow | Short chain fatty acid enriched | Short chain fatty acid enriched |
|---|---|---|---|---|
| Condition | Fed | Fast | Fed | Fast |
| Genotype comparison | MHC-Cre vs KLF15-cKO | |||
| Long chain acylcarnitines | ||||
| C14 | NC | NC | NC | + |
| C14:1 | NC | NC | NC | + |
| C14:2 | NC | ++ | NC | NC |
| C14:3 | NC | NC | NC | NC |
| C14-OH/C12-DC | NC | + | NC | + |
| C14:1-OH/C12:1-DC | NC | ++ | NC | + |
| C14:2-OH/C12:2-DC | NC | + | NC | NC |
| C14:3-OH/C12:3-DC | NC | NC | NC | NC |
| C16 | NC | + | NC | ++ |
| C16:1 | NC | NC | NC | + |
| C16:2 | NC | ++ | NC | + |
| C16:3 | NC | ++ | NC | NC |
| C16-OH/C14-DC | NC | NC | NC | + |
| C16:1-OH/C14:1-DC | NC | + | NC | + |
| C16:2-OH/C14:2-DC | NC | + | NC | NC |
| C16:3-OH/C14:3-DC | + | + | NC | NC |
| C18 | ++ | NC | NC | + |
| C18:1 | NC | + | NC | + |
| C18:2 | NC | + | NC | ++ |
| C18:3 | NC | + | NC | NC |
| C18:1-OH/C16:1-DC | NC | + | NC | + |
| C18:2-OH/C16:2-DC | NC | ++ | NC | + |
| C18:3-OH/C16:3-DC | NC | ++ | NC | NC |
| C20 | NC | ++ | NC | NC |
| C20:1 | ++ | ++ | NC | NC |
| C20:2 | ++ | NC | NC | NC |
| C20:3 | ++ | ++ | NC | ++ |
| C20:4 | NC | ++ | NC | NC |
| C20-OH/C18-DC/C22:6 | NC | NC | NC | NC |
| C20:1-OH/C18:1-DC | NC | NC | NC | NC |
| C20:2-OH/C18:2-DC | NC | NC | NC | NC |
| C20:3-OH/C18:3-DC | NC | ++ | NC | NC |
| C22 | NC | ++ | NC | NC |
| C22:1 | NC | NC | NC | NC |
| C22:2 | + | NC | NC | NC |
| C22:3 | ++ | NC | NC | NC |
| C22:4 | ++ | NC | NC | NC |
| C22:5 | NC | NC | NC | NC |
Changes in all measured long chain acylcarnitine species after loss of KLF15 expression in fed and fasted conditions, with and without SCD diet. No statistically significant difference between MHC-Cre and KLF15-cKO is represented by (NC), a less than 2 fold increase is represented by (+) and a more than 2 fold increase is represented by (++).